Apply a few drops to clean, dry skin on the face and neck in the evening. This high-strength formula should only be used by those who have built a strong tolerance to lower retinol concentrations. Begin with 1–2 times per week, gradually increasing frequency as your skin adapts. Avoid the eye area. Always use a broad-spectrum sunscreen during the day, as retinoids significantly increase photosensitivity. Patch testing is essential prior to first use.